Long-term exposure to ambient particulate matter (PM 2.5 ) is associated with platelet counts in adults.

Background: The prothrombotic effects of particulate matter (PM) may underlie the association of air pollution with increased risks of cardiovascular disease. This study aimed to investigate the association between long-term exposure to PM with an aerodynamic diameter ≤2.5 μm (PM _2.5 ) and platelet counts, a marker of coagulation profiles.
Methods: The study participants were from a cohort consisting of 362,396 Taiwanese adults who participated in a standard medical examination program between 2001 and 2014. Platelet counts were measured through Complete Blood Count tests. A satellite-based spatio-temporal model was used to estimate 2-year average ambient PM _2.5 concentration at each participant's address. Mixed-effects linear regression models were used to investigate the association between PM _2.5 exposure and platelet counts.
Results: This analysis included 175,959 men with 396,248 observations and 186,437 women with 397,877 observations. Every 10-μg/m ³ increment in the 2-year average PM _2.5 was associated with increases of 0.42% (95% CI: 0.38%, 0.47%) and 0.49% (95% CI: 0.44%, 0.54%) in platelet counts in men and women, respectively. A series of sensitivity analyses, including an analysis in participants free of cardiometabolic disorders, confirmed the robustness of the observed associations. Baseline data analyses showed that every 10-μg/m ³ increment in PM _2.5 was associated with higher risk of 17% and 14% of having elevated platelet counts (≥90th percentile) in men and women, respectively.
Conclusions: Long-term exposure to PM _2.5 appears to be associated with increased platelet counts, indicating potential adverse effects on blood coagulability.
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