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Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions.

Authors :
Schindler D
Dai J
Cai Y
Source :
Current opinion in chemical biology [Curr Opin Chem Biol] 2018 Oct; Vol. 46, pp. 56-62. Date of Electronic Publication: 2018 May 09.
Publication Year :
2018

Abstract

Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10000bps and turn-around times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-0402
Volume :
46
Database :
MEDLINE
Journal :
Current opinion in chemical biology
Publication Type :
Academic Journal
Accession number :
29751161
Full Text :
https://doi.org/10.1016/j.cbpa.2018.04.002