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The Critical, Clinical Role of Interferon-Beta in Regulating Cancer Stem Cell Properties in Triple-Negative Breast Cancer.
- Source :
-
DNA and cell biology [DNA Cell Biol] 2018 Jun; Vol. 37 (6), pp. 513-516. Date of Electronic Publication: 2018 May 11. - Publication Year :
- 2018
-
Abstract
- Triple-negative breast cancer (TNBC) the deadliest form of this disease currently lacks a targeted therapy and is characterized by increased risk of metastasis and presence of therapeutically resistant cancer stem cells (CSC). Recent evidence has demonstrated that the presence of an interferon (IFN)/signal transducer of activated transcription 1 (STAT1) gene signature correlates with improved therapeutic response and overall survival in TNBC patients. In agreement with these clinical observations, our recent work has demonstrated, in a cell model of TNBC that CSC have intrinsically repressed IFN signaling. Administration of IFN-β represses CSC properties, inducing a less aggressive non-CSC state. Moreover, an elevated IFN-β gene signature correlated with repressed CSC-related genes and an increased presence of tumor-infiltrating lymphocytes in TNBC specimens. We therefore propose that IFN-β be considered as a potential therapeutic option in the treatment of TNBC, to repress the CSC properties responsible for therapy failure. Future studies aim to improve methods to target delivery of IFN-β to tumors, to maximize therapeutic efficacy while minimizing systemic side effects.
- Subjects :
- Antineoplastic Agents pharmacology
Cell Line, Tumor
Epithelial-Mesenchymal Transition genetics
Female
Gene Expression Regulation, Neoplastic drug effects
Humans
Neoplastic Stem Cells metabolism
Triple Negative Breast Neoplasms drug therapy
Triple Negative Breast Neoplasms genetics
Triple Negative Breast Neoplasms pathology
Tumor Microenvironment genetics
Epithelial-Mesenchymal Transition drug effects
Interferon-beta pharmacology
Neoplastic Stem Cells drug effects
Tumor Microenvironment drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7430
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- DNA and cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 29750542
- Full Text :
- https://doi.org/10.1089/dna.2018.4247