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Nitrite-dependent nitric oxide synthesis by molybdenum enzymes.
- Source :
-
FEBS letters [FEBS Lett] 2018 Jun; Vol. 592 (12), pp. 2126-2139. Date of Electronic Publication: 2018 May 27. - Publication Year :
- 2018
-
Abstract
- Nitric oxide (NO) is an important gasotransmitter involved in numerous intra- and intercellular signaling events. In addition to the oxidative pathway of NO generation, which includes three NO synthase (NOS) isoforms in mammals, a reductive pathway contributes to NO generation. In this pathway, nitrite is reduced to NO by various metal-containing proteins. Among these, all members of the eukaryotic molybdenum (Mo)-dependent enzyme family were found to be able to reduce nitrite to NO. This Review focuses on the current state of research in the field of Mo-dependent nitrite reduction in eukaryotes. An overview on the five eukaryotic Mo-enzymes is given, and similarities as well as differences in their nitrite reduction mechanisms are presented and discussed in the context of physiological relevance.<br /> (© 2018 Federation of European Biochemical Societies.)
- Subjects :
- Aldehyde Oxidase chemistry
Aldehyde Oxidase metabolism
Animals
Humans
Nitrate Reductase chemistry
Nitrate Reductase metabolism
Oxidoreductases chemistry
Oxidoreductases metabolism
Protein Conformation
Sulfite Oxidase chemistry
Sulfite Oxidase metabolism
Xanthine Dehydrogenase metabolism
Biosynthetic Pathways
Molybdenum chemistry
Nitric Oxide biosynthesis
Nitrites chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 592
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 29749013
- Full Text :
- https://doi.org/10.1002/1873-3468.13089