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Discordant NIPT result in a viable trisomy-21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy-14 cotwin.
- Source :
-
Clinical case reports [Clin Case Rep] 2018 Mar 07; Vol. 6 (5), pp. 788-791. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell-free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false-positive outcome for a normal, viable twin. We show that a vanishing trisomy-14 twin contributes to cfDNA for more than 2 weeks after demise.
Details
- Language :
- English
- ISSN :
- 2050-0904
- Volume :
- 6
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical case reports
- Publication Type :
- Report
- Accession number :
- 29744057
- Full Text :
- https://doi.org/10.1002/ccr3.1424