Back to Search
Start Over
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
- Source :
-
Scientific reports [Sci Rep] 2018 May 09; Vol. 8 (1), pp. 7352. Date of Electronic Publication: 2018 May 09. - Publication Year :
- 2018
-
Abstract
- Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.
- Subjects :
- Adult
Alleles
Brain Neoplasms pathology
Case-Control Studies
Chromosomes, Human, Pair 3 genetics
Chromosomes, Human, Pair 7 genetics
Chromosomes, Human, Pair 8 genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Glioma metabolism
Glioma pathology
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide genetics
Risk Factors
Sex Factors
Glioma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29743610
- Full Text :
- https://doi.org/10.1038/s41598-018-24580-z