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The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.
- Source :
-
The American journal of pathology [Am J Pathol] 1988 Dec; Vol. 133 (3), pp. 456-63. - Publication Year :
- 1988
-
Abstract
- Two immunocytochemical probes were used to specifically identify and localize heparan sulphate proteoglycans (HSPGs) in 17 cases of Alzheimer's disease (AD). A monoclonal (HK-102) and an affinity-purified polyclonal antibody, each recognizing specific domains on the protein core of a basement membrane-derived HSPG, localized HSPGs to the amyloid fibrils present in neuritic plaques (NPs) and congophilic angiopathy (CA) in the brains of Alzheimer's patients, with weak to no immunostaining in neurofibrillary tangles from the same tissues. HSPGs were also demonstrated in "primitive plaques," suggesting that their accumulation takes place during early stages of plaque development. Immunolocalization of HSPGs to subsets of astrocytes and neuronal cells, particularly those in close proximity to NPs and CA, suggested possible involvement of these two cell types in deposition of HS-PGs into the amyloidotic lesions. The current study not only identifies a new component (HSPGs) present in the amyloid deposits of NPs and CA but also suggests that astrocytes, neurons, or both may be involved in its deposition at these sites.
- Subjects :
- Alzheimer Disease metabolism
Amyloid analysis
Antibodies, Monoclonal
Astrocytes analysis
Astrocytes ultrastructure
Brain pathology
Brain ultrastructure
Congo Red
Heparan Sulfate Proteoglycans
Humans
Immunoenzyme Techniques
Immunohistochemistry
Microscopy, Electron
Neurofibrils analysis
Neurofibrils ultrastructure
Neurons analysis
Neurons ultrastructure
Alzheimer Disease pathology
Brain Chemistry
Chondroitin Sulfate Proteoglycans analysis
Glycosaminoglycans analysis
Heparitin Sulfate analysis
Proteoglycans analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 133
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 2974240