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In Vitro Mimetic Models for the Bone-Cartilage Interface Regeneration.
- Source :
-
Advances in experimental medicine and biology [Adv Exp Med Biol] 2018; Vol. 1059, pp. 373-394. - Publication Year :
- 2018
-
Abstract
- In embryonic development, pure cartilage structures are in the basis of bone-cartilage interfaces. Despite this fact, the mature bone and cartilage structures can vary greatly in composition and function. Nevertheless, they collaborate in the osteochondral region to create a smooth transition zone that supports the movements and forces resulting from the daily activities. In this sense, all the hierarchical organization is involved in the maintenance and reestablishment of the equilibrium in case of damage. Therefore, this interface has attracted a great deal of interest in order to understand the mechanisms of regeneration or disease progression in osteoarthritis. With that purpose, in vitro tissue models (either static or dynamic) have been studied. Static in vitro tissue models include monocultures, co-cultures, 3D cultures, and ex vivo cultures, mostly cultivated in flat surfaces, while dynamic models involve the use of bioreactors and microfluidic systems. The latter have emerged as alternatives to study the cellular interactions in a more authentic manner over some disadvantages of the static models. The current alternatives of in vitro mimetic models for bone-cartilage interface regeneration are overviewed and discussed herein.
- Subjects :
- Animals
Bioreactors
Bone Diseases pathology
Bone and Bones cytology
Bone and Bones physiology
Cartilage Diseases pathology
Cartilage, Articular physiology
Chondrocytes cytology
Chondrocytes transplantation
Chondrogenesis physiology
Coculture Techniques
Humans
Lab-On-A-Chip Devices
Osteogenesis physiology
Printing, Three-Dimensional
Tissue Scaffolds
Bone Diseases therapy
Cartilage Diseases therapy
Cell Culture Techniques
Organ Culture Techniques
Tissue Engineering methods
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2598
- Volume :
- 1059
- Database :
- MEDLINE
- Journal :
- Advances in experimental medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 29736583
- Full Text :
- https://doi.org/10.1007/978-3-319-76735-2_17