Back to Search
Start Over
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
- Source :
-
Cancer letters [Cancer Lett] 2018 Aug 28; Vol. 430, pp. 1-10. Date of Electronic Publication: 2018 May 05. - Publication Year :
- 2018
-
Abstract
- Our previous work has demonstrated that extracellular ATP is an important pro-invasive factor, and in this study, we tapped into a possible mechanism involved. We discovered that ATP could upregulate both the intracellular expression and secretion of S100A4 in breast cancer cells and fibroblasts. Apart from stimulating breast cancer cell motility via intracellular S100A4, ATP enhanced the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblast (CAF)-like cells, which in turn secreted S100A4 to further promote cancer cell motility. Both apyrase and niclosamide treatments could inhibit metastasis of inoculated tumors to lung, liver and kidney in mice model, and CAFs from these treated tumors exhibited weakened migration-stimulating capacity for breast cancer cells. Collectively, our data indicate that extracellular ATP promotes the interactions between breast cancer cells and fibroblasts, which work collaboratively via production of S100A4 to exacerbate breast cancer metastasis.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Apyrase pharmacology
Cancer-Associated Fibroblasts drug effects
Female
Gene Expression Profiling
Gene Knockdown Techniques
Humans
MCF-7 Cells
Mice
Mice, Nude
Niclosamide pharmacology
Oligonucleotide Array Sequence Analysis
Primary Cell Culture
RNA, Messenger metabolism
RNA, Small Interfering metabolism
S100 Calcium-Binding Protein A4 genetics
Up-Regulation
Adenosine Triphosphate metabolism
Breast Neoplasms pathology
Cancer-Associated Fibroblasts metabolism
Cell Movement drug effects
S100 Calcium-Binding Protein A4 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 430
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 29733962
- Full Text :
- https://doi.org/10.1016/j.canlet.2018.04.043