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Dorsolateral prefrontal cortex bridges bilateral primary somatosensory cortices during cross-modal working memory.
- Source :
-
Behavioural brain research [Behav Brain Res] 2018 Sep 17; Vol. 350, pp. 116-121. Date of Electronic Publication: 2018 May 01. - Publication Year :
- 2018
-
Abstract
- Neural activity in the dorsolateral prefrontal cortex (DLPFC) has been suggested to integrate information from distinct sensory areas. However, how the DLPFC interacts with the bilateral primary somatosensory cortices (SIs) in tactile-visual cross-modal working memory has not yet been established. In the present study, we applied single-pulse transcranial magnetic stimulation (sp-TMS) over the contralateral DLPFC and bilateral SIs of human participants at various time points, while they performed a tactile-visual delayed matching-to-sample task with a 2-second delay. sp-TMS over the contralateral DLPFC or the contralateral SI at either an sensory encoding stage [i.e. 100 ms after the onset of a vibrotactile sample stimulus (200-ms duration)] or an early maintenance stage (i.e. 300 ms after the onset), significantly impaired the accuracy of task performance; sp-TMS over the contralateral DLPFC or the ipsilateral SI at a late maintenance stage (1600 ms and 1900 ms) also significantly disrupted the performance. Furthermore, at 300 ms after the onset of the vibrotactile sample stimulus, there was a significant correlation between the deteriorating effects of sp-TMS over the contralateral SI and the contralateral DLPFC. These results imply that the DLPFC and the bilateral SIs play causal roles at distinctive stages during cross-modal working memory, while the contralateral DLPFC communicates with the contralateral SI in the early delay, and cooperates with the ipsilateral SI in the late delay.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Female
Fingers physiology
Functional Laterality
Humans
Male
Neural Pathways physiology
Transcranial Magnetic Stimulation
Young Adult
Memory, Short-Term physiology
Pattern Recognition, Visual physiology
Prefrontal Cortex physiology
Somatosensory Cortex physiology
Touch Perception physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 350
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 29727709
- Full Text :
- https://doi.org/10.1016/j.bbr.2018.04.053