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[Clinical efficacy of integrated traditional Chinese and Western medicine for castration-resistant prostate cancer].
- Source :
-
Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2017 Oct; Vol. 23 (10), pp. 922-927. - Publication Year :
- 2017
-
Abstract
- Objective: To investigate the clinical effects of integrated traditional Chinese and Western medicine in the treatment of castration-resistant prostate cancer (CRPC).<br />Methods: A total of 54 CRPC patients were randomly divided into a control and a trial group, all treated by endocrine therapy (oral Bicalutamide at 50 mg per d plus subcutaneous injection of Goserelin at 3.6 mg once every 4 wk) and chemotherapy (intravenous injection of Docetaxel at 75 mg/m2 once every 3 wk plus oral Prednisone at 5 mg bid), while the latter group by Fuyang Huayu Prescription (a Traditional Chinese Medicine [TCM] prescription for tonifying yang and dispersing blood stasis) in addition, for a course of 24 weeks. Comparisons were made between the two groups of patients in the level of serum prostate-specific antigen (PSA), Karnofsky physical condition scores, function assessment of cancer therapy-prostate (FACT-P) scores, and TCM symptoms scores before and after 12 or 24 weeks of treatment.<br />Results: Compared with the baseline, the serum PSA level was significantly decreased after 12 weeks of treatment both in the control ([25.9 ± 39.3] vs [20.0 ± 21.1] μg/L, P <0.05) and in the trial group ([22.1 ± 33.9] vs [17.9 ± 19.1] μg/L, P <0.05), with no statistically significant differences between the two groups (P >0.05). At 24 weeks, however, the PSA levels in the control and trial groups were slightly increased to (23.1 ± 28.4) and (19.6 ± 23.5) μg/L, respectively, with no statistically significant differences in between (P >0.05). Karnofsky, FACT-P and TCM symptoms scores were all markedly improved in the trial group after 12 weeks of treatment (P <0.05) and remained stable at 24 weeks, but not in the control group either at 12 or at 24 weeks (P >0.05).<br />Conclusions: TCM Fuyang Huayu Prescription combined with endocrine therapy and chemotherapy is effective for CRPC.
- Subjects :
- Anilides administration & dosage
Antineoplastic Agents, Hormonal therapeutic use
Docetaxel
Drug Administration Schedule
Goserelin administration & dosage
Humans
Male
Nitriles administration & dosage
Prednisone administration & dosage
Prostate-Specific Antigen blood
Prostatic Neoplasms, Castration-Resistant blood
Taxoids administration & dosage
Tosyl Compounds administration & dosage
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Prostatic Neoplasms, Castration-Resistant drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1009-3591
- Volume :
- 23
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Zhonghua nan ke xue = National journal of andrology
- Publication Type :
- Academic Journal
- Accession number :
- 29727544