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Coronary artery calcium assessed with calibrated mass scoring in asymptomatic individuals: results from the Copenhagen General Population Study.
- Source :
-
European radiology [Eur Radiol] 2018 Nov; Vol. 28 (11), pp. 4607-4614. Date of Electronic Publication: 2018 May 03. - Publication Year :
- 2018
-
Abstract
- Background: Coronary artery calcification (CAC) is commonly assessed with Agatston score (AS). A higher sensitivity and precision for the detection of CAC has been demonstrated with calibrated mass score (cMS). We hypothesized that cMS would detect low-level CAC not detectable with AS in a large asymptomatic background population.<br />Methods: Participants (N = 2985) from the Copenhagen General Population Study were evaluated for CAC using both conventional AS and cMS. The population was grouped according to number of traditional risk factors and heart score was used to assess the risk of event for those with no CAC, those with only cMS > 0 and those with both AS and cMS > 0.<br />Results: In participants with an AS = 0, 11% had cMS > 0. The risk profile of this cMS-only group was between that of the CAC-negative participants and those with AS > 0 and cMS > 0. Overall, 6% of the population belonged to the cMS-only group independent of the number of risk factors.<br />Conclusion: In individuals with AS = 0, a fraction was found to have cMS > 0. Based on traditional risk factors, this group has a higher 10-year risk than individuals with both AS = 0 and cMS = 0; cMS might offer very early cardiovascular risk assessment in asymptomatic individuals.<br />Key Points: • In individuals with AS=0, a fraction has CAC with highly sensitive cMS. • This fraction has a higher 10-year risk of cardiovascular disease. • Regardless of risk factors, 6% has CAC detectable only with cMS. • cMS might offer very early cardiovascular risk assessment in asymptomatic individuals.
- Subjects :
- Aged
Asymptomatic Diseases
Coronary Artery Disease epidemiology
Denmark epidemiology
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
ROC Curve
Risk Factors
Severity of Illness Index
Vascular Calcification epidemiology
Coronary Angiography methods
Coronary Artery Disease diagnosis
Coronary Vessels diagnostic imaging
Multidetector Computed Tomography methods
Population Surveillance
Risk Assessment
Vascular Calcification diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 29725832
- Full Text :
- https://doi.org/10.1007/s00330-018-5446-7