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Combination of urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate for the treatment of inflammatory lung diseases: An in vitro study.
- Source :
-
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2018 Jul 30; Vol. 120, pp. 96-106. Date of Electronic Publication: 2018 Apr 30. - Publication Year :
- 2018
-
Abstract
- This in vitro study evaluated, for the first time, the safety and the biological activity of a novel urea-crosslinked hyaluronic acid component and sodium ascorbyl phosphate (HA-CL - SAP), singularly and/or in combination, intended for the treatment of inflammatory lung diseases. The aim was to understand if the combination HA-CL - SAP had an enhanced activity with respect to the combination native hyaluronic acid (HA) - SAP and the single SAP, HA and HA-CL components. Sample solutions displayed pH, osmolality and viscosity values suitable for lung delivery and showed to be not toxic on epithelial Calu-3 cells at the concentrations used in this study. The HA-CL - SAP displayed the most significant reduction in interleukin-6 (IL-6) and reactive oxygen species (ROS) levels, due to the combined action of HA-CL and SAP. Moreover, this combination showed improved cellular healing (wound closure) with respect to HA - SAP, SAP and HA, although at a lower rate than HA-CL alone. These preliminary results showed that the combination HA-CL - SAP could be suitable to reduce inflammation and oxidative stress in lung disorders like acute respiratory distress syndrome, asthma, emphysema and chronic obstructive pulmonary disease, where inflammation is prominent.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents toxicity
Antioxidants administration & dosage
Antioxidants toxicity
Ascorbic Acid administration & dosage
Ascorbic Acid chemistry
Ascorbic Acid toxicity
Cell Line, Tumor
Cell Survival drug effects
Dose-Response Relationship, Drug
Drug Combinations
Drug Compounding
Electric Impedance
Epithelial Cells drug effects
Epithelial Cells metabolism
Humans
Hyaluronic Acid administration & dosage
Hyaluronic Acid toxicity
Hydrogen-Ion Concentration
Interleukin-6 metabolism
Lung metabolism
Lung pathology
Lung Diseases, Obstructive metabolism
Lung Diseases, Obstructive pathology
Osmolar Concentration
Reactive Oxygen Species metabolism
Technology, Pharmaceutical methods
Viscosity
Anti-Inflammatory Agents chemistry
Antioxidants chemistry
Ascorbic Acid analogs & derivatives
Cross-Linking Reagents chemistry
Hyaluronic Acid chemistry
Lung drug effects
Lung Diseases, Obstructive drug therapy
Urea chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0720
- Volume :
- 120
- Database :
- MEDLINE
- Journal :
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29723596
- Full Text :
- https://doi.org/10.1016/j.ejps.2018.04.042