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Pulmonary Vasoreactivity and Phenotypes in Pulmonary Arterial Hypertension Associated to Connective Tissue Diseases.
- Source :
-
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion [Rev Invest Clin] 2018; Vol. 70 (2), pp. 82-7. - Publication Year :
- 2018
-
Abstract
- Background: Pulmonary arterial hypertension (PAH) is a fatal complication in patients with connective tissue disease (CTD).<br />Objective: The objective of the study was to study the prognostic value of the acute pulmonary vasoreactivity test with inhaled iloprost and its association with clinical deterioration in a tertiary care academic medical center.<br />Methods: We conducted a prospective study of patients with CTD and the diagnosis of PAH established by right heart catheterization. Patients were classified into classic responders, partial responders, and non-responders. The association of the pulmonary response and clinical deterioration was analyzed.<br />Results: We enrolled 25 patients (mean age of 47 ± 13.4 years); 88% were female. The most frequent rheumatologic diagnosis was systemic lupus erythematosus, in 16 (64%) patients. Seventy-two percent of patients were classified as non-responders, and 28% were partial responders. Patients with a partial response had lower right atrial pressure values (5.1 ± 3.1 vs. 8.5 ± 3.2, p = 0.01) and greater systolic pulmonary arterial pressure (87.6 ± 8.1 vs. 72.4 ± 16.2, p = 0.02), compared with non-responders. Non-responders had a tendency for a shorter time to clinical deterioration than partial responders (17.8 vs. 41.1 months, p = 0.052).<br />Conclusions: Patients with a partial response to the acute pulmonary vasodilator test with inhaled iloprost had a longer clinical deterioration-free period than non-responders.<br /> (Copyright: © 2017 SecretarÍa de Salud.)
- Subjects :
- Administration, Inhalation
Adult
Blood Pressure
Cardiac Catheterization methods
Connective Tissue Diseases physiopathology
Female
Humans
Hypertension, Pulmonary physiopathology
Male
Middle Aged
Phenotype
Prognosis
Prospective Studies
Time Factors
Vasodilator Agents administration & dosage
Connective Tissue Diseases complications
Hypertension, Pulmonary diagnosis
Iloprost administration & dosage
Lupus Erythematosus, Systemic complications
Subjects
Details
- Language :
- English
- ISSN :
- 0034-8376
- Volume :
- 70
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
- Publication Type :
- Academic Journal
- Accession number :
- 29718009
- Full Text :
- https://doi.org/10.24875/RIC.18002437