Efficient Sialyltransferase Inhibitors Based on Transition-State Analogues of the Sialyl Donor.

Authors :: Müller B
Schaub C
Schmidt RR
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 1998 Nov 02; Vol. 37 (20), pp. 2893-2897.
Publication Year :: 1998
Abstract: A 200- to 1000-fold higher affinity for sialyltransferase is shown by compounds 1 and 2 relative to the natural substrate. These inhibitors, which are derived from the transition state of S <subscript>N</subscript> 1-type sialyltransfer, contain a flat ring that is attached through a carbon atom with a phosphonate and a cytidine monophosphate group.<br /> (© 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.)

Language :: English
ISSN :: 1521-3773
Volume :: 37
Issue :: 20
Database :: MEDLINE
Journal :: Angewandte Chemie (International ed. in English)
Publication Type :: Academic Journal
Accession number :: 29711111
Full Text :: https://doi.org/10.1002/(SICI)1521-3773(19981102)37:20<2893::AID-ANIE2893>3.0.CO;2-W

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