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Fibroblast growth factor 23 and renal function among young and healthy individuals.

Authors :
Bernasconi R
Aeschbacher S
Blum S
Mongiat M
Girod M
Todd J
Estis J
Nolan N
Renz H
Risch L
Conen D
Risch M
Source :
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2018 Aug 28; Vol. 56 (9), pp. 1483-1489.
Publication Year :
2018

Abstract

Background: Fibroblast growth factor 23 (FGF-23), an osteocyte hormone involved in the regulation of phosphate metabolism, is associated with incident and progressive chronic kidney disease. We aimed to assess the association of FGF-23 with renal parameters, vascular function and phosphate metabolism in a large cohort of young and healthy individuals.<br />Methods: Healthy individuals aged 25-41 years were included in a prospective population-based study. Fasting venous blood and morning urinary samples were used to measure plasma creatinine, cystatin C, endothelin-1, phosphate and plasma FGF-23 as well as urinary creatinine and phosphate. Multivariable regression models were constructed to assess the relationship of FGF-23 with parameters of renal function, endothelin-1 and fractional phosphate excretion.<br />Results: The median age of 2077 participants was 37 years, 46% were males. The mean estimated glomerular filtration rate (eGFR - CKD-EPI creatinine-cystatin C equation) and fractional phosphate excretion were 110 mL/min/1.73 m2 and 8.7%, respectively. After multivariable adjustment, there was a significant inverse relationship of FGF-23 with eGFR (β per 1 log-unit increase -3.81; 95% CI [-5.42; -2.20]; p<0.0001). Furthermore, we found a linear association between FGF-23 and endothelin-1 (β per 1 log-unit increase 0.06; [0.01, 0.11]; p=0.01). In addition, we established a significant relationship of FGF-23 with fractional phosphate excretion (β per 1 log-unit increase 0.62; [0.08, 1.16]; p=0.03).<br />Conclusions: Increasing plasma FGF-23 levels are strongly associated with decreasing eGFR and increasing urinary phosphate excretion, suggesting an important role of FGF-23 in the regulation of kidney function in young and healthy adults.

Details

Language :
English
ISSN :
1437-4331
Volume :
56
Issue :
9
Database :
MEDLINE
Journal :
Clinical chemistry and laboratory medicine
Publication Type :
Academic Journal
Accession number :
29708879
Full Text :
https://doi.org/10.1515/cclm-2017-1183