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Bioactive Compounds of Kimchi Inhibit Apoptosis by Attenuating Endoplasmic Reticulum Stress in the Brain of Amyloid β-Injected Mice.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2018 May 16; Vol. 66 (19), pp. 4883-4890. Date of Electronic Publication: 2018 May 07. - Publication Year :
- 2018
-
Abstract
- This study investigated the inhibitory effects of kimchi bioactive compounds against endoplasmic reticulum (ER) stress-induced apoptosis in amyloid beta (Aβ)-injected mice. Mice received a single intracerebroventricular injection of Aβ <subscript>25-35</subscript> , except for the normal group. Mice were subjected to oral administration of 10 mg of capsaicin, 50 mg of 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA), 50 mg of quercetin, 50 mg of ascorbic acid, or 200 mg of kimchi methanol extract (KME) per kilogram of body weight for 2 weeks ( n = 7 per group). In the in vitro blood-brain barrier (BBB) permeability test, all bioactive compounds penetrated the BBB except ascorbic acid. The protein expression level of APP, BACE, and p-Tau elevated by Aβ injection was decreased by kimchi bioactive compounds ( P < 0.05). Quercetin, HDMPPA, and KME decreased oxidative stress, as indicated by ROS and TBARS levels ( P < 0.05). The protein expression level of ER stress markers GRP78, p-PERK, p-eIF2α, XBP1, and CHOP and the proapoptotic molecules Bax, p-JNK, and cleaved caspases-3 and -9 decreased ( P < 0.05). In contrast, the protein expression level of antiapoptotic molecules Bcl2 and cIAP increased ( P < 0.05). These results were supported by histological analysis.
- Subjects :
- Alzheimer Disease genetics
Alzheimer Disease metabolism
Alzheimer Disease physiopathology
Amyloid beta-Peptides administration & dosage
Animals
Blood-Brain Barrier drug effects
Blood-Brain Barrier metabolism
Brain cytology
Brain metabolism
Caspase 3 genetics
Caspase 3 metabolism
Endoplasmic Reticulum Chaperone BiP
Fermented Foods analysis
Humans
Infusions, Intraventricular
Male
Mice
Mice, Inbred ICR
Oxidative Stress drug effects
Peptide Fragments administration & dosage
Signal Transduction drug effects
X-Box Binding Protein 1 genetics
X-Box Binding Protein 1 metabolism
Alzheimer Disease drug therapy
Amyloid beta-Peptides toxicity
Apoptosis drug effects
Brain drug effects
Brassica chemistry
Endoplasmic Reticulum Stress drug effects
Peptide Fragments toxicity
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 66
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29706080
- Full Text :
- https://doi.org/10.1021/acs.jafc.8b01686