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Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE).
- Source :
-
PloS one [PLoS One] 2018 Apr 26; Vol. 13 (4), pp. e0196486. Date of Electronic Publication: 2018 Apr 26 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Purpose: Although it has been known for decades that patients with alpha1-antitrypsin deficiency (AATD) have an increased risk of cirrhosis and hepatocellular carcinoma, limited data exist on non-invasive imaging-based methods for assessing liver fibrosis such as magnetic resonance elastography (MRE) and acoustic radiation force impulse (ARFI) quantification, and no data exist on 2D-shear wave elastography (2D-SWE). Therefore, the purpose of this study is to evaluate and compare the applicability of different elastography methods for the assessment of AATD-related liver fibrosis.<br />Methods: Fifteen clinically asymptomatic AATD patients (11 homozygous PiZZ, 4 heterozygous PiMZ) and 16 matched healthy volunteers were examined using MRE and ARFI quantification. Additionally, patients were examined with 2D-SWE.<br />Results: A high correlation is evident for the shear wave speed (SWS) determined with different elastography methods in AATD patients: 2D-SWE/MRE, ARFI quantification/2D-SWE, and ARFI quantification/MRE (R = 0.8587, 0.7425, and 0.6914, respectively; P≤0.0089). Four AATD patients with pathologically increased SWS were consistently identified with all three methods-MRE, ARFI quantification, and 2D-SWE.<br />Conclusion: The high correlation and consistent identification of patients with pathologically increased SWS using MRE, ARFI quantification, and 2D-SWE suggest that elastography has the potential to become a suitable imaging tool for the assessment of AATD-related liver fibrosis. These promising results provide motivation for further investigation of non-invasive assessment of AATD-related liver fibrosis using elastography.
- Subjects :
- Adult
Aged
Body Mass Index
Case-Control Studies
Female
Genotype
Humans
Liver Cirrhosis complications
Liver Cirrhosis pathology
Male
Middle Aged
Prospective Studies
alpha 1-Antitrypsin blood
alpha 1-Antitrypsin genetics
alpha 1-Antitrypsin Deficiency complications
alpha 1-Antitrypsin Deficiency genetics
Elasticity Imaging Techniques methods
Liver diagnostic imaging
Liver Cirrhosis diagnostic imaging
alpha 1-Antitrypsin Deficiency diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 29698472
- Full Text :
- https://doi.org/10.1371/journal.pone.0196486