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Ambient PM 2.5 air pollution exposure and hepatocellular carcinoma incidence in the United States.
- Source :
-
Cancer causes & control : CCC [Cancer Causes Control] 2018 Jun; Vol. 29 (6), pp. 563-572. Date of Electronic Publication: 2018 Apr 25. - Publication Year :
- 2018
-
Abstract
- Purpose: To conduct the first epidemiologic study prospectively examining the association between particulate matter air pollution < 2.5 µm in diameter (PM <subscript>2.5</subscript> ) exposure and hepatocellular carcinoma (HCC) risk in the U.S.<br />Methods: Surveillance, Epidemiology, and End Results (SEER) provided information on HCC cases diagnosed between 2000 and 2014 from 16 population-based cancer registries across the U.S. Ambient PM <subscript>2.5</subscript> exposure was estimated by linking the SEER county with a spatial PM <subscript>2.5</subscript> model using a geographic information system. Poisson regression with robust variance estimation was used to calculate incidence rate ratios and 95% confidence intervals (CIs) for the association between ambient PM <subscript>2.5</subscript> exposure per 10 µg/m <superscript>3</superscript> increase and HCC risk adjusting for individual-level age at diagnosis, sex, race, year of diagnosis, SEER registry, and county-level information on health conditions, lifestyle, demographic, socioeconomic, and environmental factors.<br />Results: Higher levels of ambient PM <subscript>2.5</subscript> exposure were associated with a statistically significant increased risk for HCC (n = 56,245 cases; adjusted IRR per 10 µg/m <superscript>3</superscript> increase = 1.26, 95% CI 1.08, 1.47; p < 0.01).<br />Conclusions: If confirmed in studies with individual-level PM <subscript>2.5</subscript> exposure and risk factor information, these results suggest that ambient PM <subscript>2.5</subscript> exposure may be a risk factor for HCC in the U.S.
- Subjects :
- Aged
Air Pollutants adverse effects
Environmental Exposure adverse effects
Female
Geographic Information Systems
Humans
Incidence
Male
Middle Aged
Registries
Risk Factors
SEER Program
United States epidemiology
Air Pollution adverse effects
Carcinoma, Hepatocellular epidemiology
Liver Neoplasms epidemiology
Particulate Matter adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7225
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer causes & control : CCC
- Publication Type :
- Academic Journal
- Accession number :
- 29696510
- Full Text :
- https://doi.org/10.1007/s10552-018-1036-x