Back to Search
Start Over
Mucin expression profile of benign and malignant cervical tissues and correlation with clinical-pathologic parameters.
- Source :
-
European journal of gynaecological oncology [Eur J Gynaecol Oncol] 2017; Vol. 38 (3), pp. 350-355. - Publication Year :
- 2017
-
Abstract
- Purpose: To detect the expression of mucins in diverse benign and malignant cervical tissues of cervical disease.<br />Materials and Methods: 158 cases of cervical tissues were collected. Sections were stained with monoclonal antibodies against MUC1, MUC2, MIUC4, MUC5AC, and MUC20 by immunohistochemistry.<br />Results: Normal cervical epithelium showed high expr ession of MUC1I, MUC4, and MUC5AC, partial expression of MUC20, and no MUC2. With the development from chronic cervicitis, cervical intraepithelial neoplasia (CI7N) to cervical squamous cell carcinoma (SCC), the expression of MUC1, NMUC4, and MUC20 was statistically significant. The expression of MUCl was related with the depth of invasion and clinical stage of SCC. The positive rates of MUC4 and MUC20 were associated with the degree of differentiation and clinical stage of SCC. There was a correlation between the expression of MUC4, MUC 1, and MUC20 in cervical squamous lesions.<br />Conclusion: Mucins may be involved in the development of cervical cancer.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell pathology
Cervix Uteri chemistry
Female
Humans
Immunohistochemistry
Middle Aged
Uterine Cervical Neoplasms etiology
Uterine Cervical Neoplasms pathology
Uterine Cervical Dysplasia pathology
Carcinoma, Squamous Cell chemistry
Mucins analysis
Uterine Cervical Neoplasms chemistry
Uterine Cervical Dysplasia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0392-2936
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of gynaecological oncology
- Publication Type :
- Academic Journal
- Accession number :
- 29693871