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A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?
- Source :
-
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2018; Vol. 18 (14), pp. 1168-1174. - Publication Year :
- 2018
-
Abstract
- In the past decades, many efforts were undertaken to develop ligands for the adenosine receptors, with the purpose to individuate agonists and antagonists affinity and selectivity for each subtypes, namely A1, A2A, A2B, and A3. These intense studies allowed a deeper knowledge of the nature and, moreover, of the pathophysiological roles of all the adenosine receptor subtypes. In particular, the involvement of the A2A adenosine receptor subtype in some physiological mechanisms in the brain, that could be related to important diseases such as the Parkinson's disease, encouraged the research in this field. Particular attention was given to the antagonists endowed with high affinity and selectivity since they could have a real employment in the treatment of Parkinson's disease, and some compounds, such as istradefylline, preladenant and tozadenant, are already studied in clinical trials. Actually, the role of A2A antagonists in Parkinson's disease is becoming contradictory due to contrasting results in the last studies, but, at the same time, new possible employments are emerging for this class of antagonists in cancer pathologies as much interesting to legitimate further efforts in the research of A2A ligands.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Adenosine A2 Receptor Antagonists chemistry
Bridged Bicyclo Compounds chemistry
Bridged Bicyclo Compounds metabolism
Bridged Bicyclo Compounds therapeutic use
Caffeine chemistry
Caffeine metabolism
Caffeine therapeutic use
Dopamine Agents chemistry
Dopamine Agents metabolism
Dopamine Agents therapeutic use
Humans
Neoplasms drug therapy
Neoplasms pathology
Parkinson Disease pathology
Receptor, Adenosine A2A chemistry
Xanthines chemistry
Xanthines metabolism
Xanthines therapeutic use
Adenosine A2 Receptor Antagonists therapeutic use
Parkinson Disease drug therapy
Receptor, Adenosine A2A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5607
- Volume :
- 18
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Mini reviews in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29692248
- Full Text :
- https://doi.org/10.2174/1389557518666180423113051