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Foxo transcription factors in T cell biology and tumor immunity.
- Source :
-
Seminars in cancer biology [Semin Cancer Biol] 2018 Jun; Vol. 50, pp. 13-20. Date of Electronic Publication: 2018 Apr 21. - Publication Year :
- 2018
-
Abstract
- The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells. We also discuss the emerging evidence on Foxo-mediated regulation in antitumor immunity. Future work will further explore how the Foxo-dependent programs in T cells can be exploited for cancer immunotherapy.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-3650
- Volume :
- 50
- Database :
- MEDLINE
- Journal :
- Seminars in cancer biology
- Publication Type :
- Academic Journal
- Accession number :
- 29684436
- Full Text :
- https://doi.org/10.1016/j.semcancer.2018.04.006