Back to Search Start Over

Foxo transcription factors in T cell biology and tumor immunity.

Authors :
Luo CT
Li MO
Source :
Seminars in cancer biology [Semin Cancer Biol] 2018 Jun; Vol. 50, pp. 13-20. Date of Electronic Publication: 2018 Apr 21.
Publication Year :
2018

Abstract

The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells. We also discuss the emerging evidence on Foxo-mediated regulation in antitumor immunity. Future work will further explore how the Foxo-dependent programs in T cells can be exploited for cancer immunotherapy.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1096-3650
Volume :
50
Database :
MEDLINE
Journal :
Seminars in cancer biology
Publication Type :
Academic Journal
Accession number :
29684436
Full Text :
https://doi.org/10.1016/j.semcancer.2018.04.006