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An increased waist-to-hip ratio is a key determinant of atherosclerotic burden in overweight subjects.
- Source :
-
Acta diabetologica [Acta Diabetol] 2018 Jul; Vol. 55 (7), pp. 741-749. Date of Electronic Publication: 2018 Apr 21. - Publication Year :
- 2018
-
Abstract
- Aims: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR).<br />Methods: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25-29.9 kg/m <superscript>2</superscript> and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease. Patients were stratified in high WHR (H-WHR) or low WHR (L-WHR) group according to WHR (≥ 0.85 for women and ≥ 0.90 for men) and underwent multi-detector computed tomography for CACs. Mean carotid intima-media thickness (IMT) and plaque presence were equally assessed.<br />Results: CACs was higher in the H-WHR group compared to L-WHR (9.05 [0.0-83.48] vs 0.0 [0.0-64.7] AU, p < 0.01); the prevalence of CACs > 0 in the H-WHR group was significantly higher than subjects with L-WHR (59.6% vs 38.5%, p < 0.001). Moreover, H-WHR group had higher mean IMT (0.64 [0.56-0.72] vs 0.59 [0.55-0.67] mm, p < 0.05) and higher carotid plaque prevalence (63.7% vs 50.8%, p < 0.05) compared to subjects with L-WHR. Logistic regression showed that H-WHR was associated with presence of CACs and carotid plaque (p < 0.01). In a multiple linear regression, WHR was positively associated with CACs and IMT (p < 0.01).<br />Conclusions: H-WHR is a marker of coronary and peripheral atherosclerotic burden in overweight patients.
- Subjects :
- Adult
Aged
Body Mass Index
Cardiovascular Diseases epidemiology
Carotid Intima-Media Thickness statistics & numerical data
Coronary Artery Disease epidemiology
Coronary Artery Disease etiology
Cross-Sectional Studies
Disease Progression
Female
Humans
Male
Middle Aged
Obesity, Abdominal complications
Obesity, Abdominal epidemiology
Plaque, Atherosclerotic epidemiology
Prevalence
Risk Factors
Severity of Illness Index
Atherosclerosis epidemiology
Atherosclerosis etiology
Overweight complications
Overweight epidemiology
Waist-Hip Ratio statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1432-5233
- Volume :
- 55
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Acta diabetologica
- Publication Type :
- Academic Journal
- Accession number :
- 29680968
- Full Text :
- https://doi.org/10.1007/s00592-018-1144-9