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Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.
- Source :
-
Genomics [Genomics] 2019 Jul; Vol. 111 (4), pp. 737-743. Date of Electronic Publication: 2018 Apr 18. - Publication Year :
- 2019
-
Abstract
- Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, P = 7.76 × 10 <superscript>-9</superscript> ). The same locus had borderline association with TPOAb levels in females (rs1935377, P = 8.58 × 10 <superscript>-8</superscript> ). In conclusion, we identified a novel gender specific locus associated with TgAb and TPOAb levels. Our findings provide a novel insight into genetic and gender differences associated with thyroid antibodies.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Autoantibodies blood
Autoantibodies immunology
Croatia
Female
Humans
Iodide Peroxidase immunology
Male
Middle Aged
Sex Factors
Thyroglobulin immunology
Calcium-Binding Proteins genetics
Membrane Proteins genetics
Polymorphism, Single Nucleotide
Receptors, N-Methyl-D-Aspartate genetics
Thyroiditis, Autoimmune genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8646
- Volume :
- 111
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 29678681
- Full Text :
- https://doi.org/10.1016/j.ygeno.2018.04.012