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IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF + innate T cells in the human liver.
- Source :
-
European journal of immunology [Eur J Immunol] 2018 Aug; Vol. 48 (8), pp. 1329-1335. Date of Electronic Publication: 2018 May 25. - Publication Year :
- 2018
-
Abstract
- Innate lymphocytes are selectively enriched in the liver where they have important roles in liver immunology. Murine studies have shown that type I NKT cells can promote liver inflammation, whereas type II NKT cells have an anti-inflammatory role. In humans, type II NKT cells were found to accumulate in the gut during inflammation and IL13Rα2 was proposed as a marker for these cells. In the human liver, less is known about type I and II NKT cells. Here, we studied the phenotype and function of human liver T cells expressing IL13Rα2. We found that IL13Rα2 was expressed by around 1% of liver-resident memory T cells but not on circulating T cells. In support of their innate-like T-cell character, the IL13Rα2 <superscript>+</superscript> T cells had higher expression of promyelocytic leukaemia zinc finger (PLZF) compared to IL13Rα2 <superscript>-</superscript> T cells and possessed the capacity to produce IL-22. However, only a minority of human liver sulfatide-reactive type II NKT cells expressed IL13Rα2. Collectively, these findings suggest that IL13Rα2 identifies tissue-resident intrahepatic T cells with innate characteristics and the capacity to produce IL-22.<br /> (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 48
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29677387
- Full Text :
- https://doi.org/10.1002/eji.201747334