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Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis.
- Source :
-
Indian journal of pharmacology [Indian J Pharmacol] 2017 Nov-Dec; Vol. 49 (6), pp. 470-471. - Publication Year :
- 2017
-
Abstract
- We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.<br />Competing Interests: There are no conflicts of interest.
- Subjects :
- Aged
Antifungal Agents administration & dosage
Antifungal Agents therapeutic use
Drug Interactions
Female
Foot Dermatoses microbiology
Humans
Iatrogenic Disease
Itraconazole administration & dosage
Itraconazole therapeutic use
Metrorrhagia diagnosis
Onychomycosis microbiology
Simvastatin administration & dosage
Simvastatin adverse effects
Simvastatin therapeutic use
Antifungal Agents adverse effects
Foot Dermatoses drug therapy
Itraconazole adverse effects
Metrorrhagia chemically induced
Onychomycosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1998-3751
- Volume :
- 49
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Indian journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 29674803
- Full Text :
- https://doi.org/10.4103/ijp.IJP_838_16