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Cost-effectiveness analysis of a fixed-dose combination of indacaterol and glycopyrronium as maintenance treatment for COPD.
- Source :
-
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2018 Apr 04; Vol. 13, pp. 1079-1088. Date of Electronic Publication: 2018 Apr 04 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Objective: The aim of this study was to evaluate the cost-effectiveness of the long-acting beta-2 agonist (LABA)/long-acting muscarinic antagonist (LAMA) dual bronchodilator indacaterol/glycopyrronium (IND/GLY) as a maintenance treatment for COPD patients from the perspective of health care payer in Taiwan.<br />Patients and Methods: We adopted a patient-level simulation model, which included a cohort of COPD patients aged ≥40 years. The intervention used in the study was the treatment using IND/GLY, and comparators were tiotropium or salmeterol/fluticasone combination (SFC). Data related to the efficacy of drugs, incidence of exacerbation, and utility were obtained from clinical studies. Direct costs were estimated from claims data based on the severity of COPD. The cycle length was 6 months (to match forced expiratory volume in 1 second [FEV <subscript>1</subscript> ] data), and the time horizons included 1, 3, 5, 10 years, and lifetime. Deterministic and probabilistic sensitivity analyses were conducted to test the robustness of the model results. Costs were expressed in US dollars with a discount rate of 3.0%.<br />Results: Compared to tiotropium and SFC, the incremental cost-effectiveness ratios (ICERs) per quality-adjusted life year (QALY) gained of patients treated with IND/GLY were US$5,987 and US$14,990, respectively. One-way sensitivity analysis revealed that the improvement in FEV <subscript>1</subscript> provided by IND/GLY, the distribution of patients with regard to the severity of COPD, and acute exacerbation rate ratio were the key drivers behind cost-effectiveness. Adopting a willingness to pay of US$60,000 per QALY gained as the threshold, there was a 98.7% probability that IND/GLY was cost-effective compared to tiotropium. Similarly, there was a 99.9% probability that IND/GLY was cost-effective compared to SFC.<br />Conclusion: As a maintenance treatment for COPD, we consider the dual bronchodilator IND/GLY as a cost-effective strategy when compared to either tiotropium or SFC.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.
- Subjects :
- Adrenergic beta-2 Receptor Agonists adverse effects
Adult
Bronchodilator Agents adverse effects
Computer Simulation
Cost-Benefit Analysis
Disease Progression
Drug Combinations
Female
Forced Expiratory Volume
Glycopyrrolate adverse effects
Humans
Indans adverse effects
Lung physiopathology
Male
Models, Economic
Muscarinic Antagonists adverse effects
Pulmonary Disease, Chronic Obstructive diagnosis
Pulmonary Disease, Chronic Obstructive physiopathology
Quality of Life
Quality-Adjusted Life Years
Quinolones adverse effects
Severity of Illness Index
Taiwan
Time Factors
Treatment Outcome
Adrenergic beta-2 Receptor Agonists administration & dosage
Adrenergic beta-2 Receptor Agonists economics
Bronchodilator Agents administration & dosage
Bronchodilator Agents economics
Drug Costs
Glycopyrrolate administration & dosage
Glycopyrrolate economics
Indans administration & dosage
Indans economics
Lung drug effects
Muscarinic Antagonists administration & dosage
Muscarinic Antagonists economics
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive economics
Quinolones administration & dosage
Quinolones economics
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2005
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- International journal of chronic obstructive pulmonary disease
- Publication Type :
- Academic Journal
- Accession number :
- 29670344
- Full Text :
- https://doi.org/10.2147/COPD.S159103