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BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia.
- Source :
-
Scientific reports [Sci Rep] 2018 Apr 18; Vol. 8 (1), pp. 6189. Date of Electronic Publication: 2018 Apr 18. - Publication Year :
- 2018
-
Abstract
- Little is known about the association of the BCL3-PVRL2-TOMM40 SNPs and dyslipidemia. This study was to detect 12 BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia in the Chinese Maonan population. Genotyping was performed in 1130 normal and 832 dyslipidemia participants. Generalized multifactor dimensionality reduction was used to screen the best interaction combination among SNPs and environmental exposures. Allele and genotype frequencies of the detected SNPs were different between the two groups (P < 0.05-0.001). Association of the 12 SNPs and serum lipid levels was observed (P < 0.004-0.001). Multiple-locus linkage disequilibrium was not statistically independent in the population (D' = 0.01-0.98). The dominant model of rs8100239 and rs157580 SNPs, several haplotypes and G × G interaction haplotypes contributed to a protection, whereas the dominant model of rs10402271, rs3810143, rs519113, rs6859 SNPs, another haplotypes and G × G interaction haplotypes revealed an increased morbidity function (P < 0.05-0.001). There were significant three-locus model involving SNP-SNP, SNP-environment, haplotype-haplotype interactions (P < 0.05-0.001). The subjects carrying several genotypes and haplotypes decreased dyslipidemia risk, whereas the subjects carrying other genotypes and haplotypes increased dyslipidemia risk. The BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia were observed in the Chinese Maonan population.
- Subjects :
- Alleles
B-Cell Lymphoma 3 Protein
Biomarkers
China
Dyslipidemias metabolism
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Haplotypes
High-Throughput Nucleotide Sequencing
Humans
Life Style
Linkage Disequilibrium
Lipids blood
Male
Mitochondrial Precursor Protein Import Complex Proteins
Dyslipidemias etiology
Epistasis, Genetic
Gene-Environment Interaction
Membrane Transport Proteins genetics
Nectins genetics
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins genetics
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29670124
- Full Text :
- https://doi.org/10.1038/s41598-018-24432-w