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Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine.
- Source :
-
Cellular immunology [Cell Immunol] 2018 Jul; Vol. 329, pp. 27-30. Date of Electronic Publication: 2018 Apr 11. - Publication Year :
- 2018
-
Abstract
- Intranasal vaccination of pigs with poly lactic-co-glycolic acid and polyanhydride nanoparticles delivered inactivated influenza virus provides cross-reactive T-cell response, but not antibody response, resulting in incomplete protection and no reduction in nasal virus shedding. Expression of BAFF and Th2 transcription factor GATA-3 were downregulated in lungs of pigs vaccinated with influenza nanovaccine, but in mice it upregulated the expression of BAFF and cytokine TGFβ in cervical lymph nodes. However, the intranasal iNKT cell adjuvant, α-Galctosylceramide upregulates the expression of BAFF in pig lungs. In conclusion, expression of BAFF is differentially regulated by intranasal nanovaccine and α-Galctosylceramide in pig respiratory tract.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Administration, Intranasal methods
Animals
B-Cell Activating Factor genetics
Chemotherapy, Adjuvant methods
Gene Expression Regulation
Influenza Vaccines administration & dosage
Killer Cells, Natural physiology
Mice
Nanoparticles therapeutic use
Polyanhydrides pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer pharmacology
Swine immunology
Swine virology
B-Cell Activating Factor drug effects
Influenza Vaccines pharmacology
Orthomyxoviridae Infections prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2163
- Volume :
- 329
- Database :
- MEDLINE
- Journal :
- Cellular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29665972
- Full Text :
- https://doi.org/10.1016/j.cellimm.2018.04.005