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Central and regional hemodynamic effects of oral enoximone in congestive heart failure: a double-blind, placebo-controlled study.

Authors :
Leier CV
Lima JJ
Meiler SE
Unverferth DV
Source :
American heart journal [Am Heart J] 1988 May; Vol. 115 (5), pp. 1051-9.
Publication Year :
1988

Abstract

Twelve patients with congestive heart failure underwent a double-blind, placebo-controlled study for the purpose of examining the central and regional hemodynamic effects of first-dose (1 and 2 mg/kg) oral enoximone, a new phosphodiesterase III inhibitor. Enoximone augmented cardiac output, generally through a positive chronotropic response. Indices of left ventricular contractility, specifically stroke volume, delta P/delta t, fractional shortening rate, and the duration of the preejection period, were only modestly enhanced by enoximone. At 2 mg/kg, systemic vascular resistance fell below baseline values without affecting systemic blood pressure; these parameters were not altered by the 1 mg/kg dose. Both pulmonary artery pressure and pulmonary vascular resistance dropped below baseline and below placebo control for the 2 mg/kg dose. Enoximone at 2 mg/kg lowered right and left heart filling pressures below baseline. Examination of regional hemodynamic responses to both doses demonstrated a reduction in limb vascular resistance and an increase in limb blood flow proportional to the concomitant increase in cardiac output. Renal and hepatic-splanchnic blood flow and vascular resistances were not altered by enoximone. First-dose oral enoximone (1 and 2 mg/kg) alters hemodynamics in heart failure by predominant vasodilatation, particularly of limb-musculoskeletal and pulmonary vascular beds, some positive chronotropism, and modest positive inotropism.

Details

Language :
English
ISSN :
0002-8703
Volume :
115
Issue :
5
Database :
MEDLINE
Journal :
American heart journal
Publication Type :
Academic Journal
Accession number :
2966546
Full Text :
https://doi.org/10.1016/0002-8703(88)90076-2