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Central and regional hemodynamic effects of oral enoximone in congestive heart failure: a double-blind, placebo-controlled study.
- Source :
-
American heart journal [Am Heart J] 1988 May; Vol. 115 (5), pp. 1051-9. - Publication Year :
- 1988
-
Abstract
- Twelve patients with congestive heart failure underwent a double-blind, placebo-controlled study for the purpose of examining the central and regional hemodynamic effects of first-dose (1 and 2 mg/kg) oral enoximone, a new phosphodiesterase III inhibitor. Enoximone augmented cardiac output, generally through a positive chronotropic response. Indices of left ventricular contractility, specifically stroke volume, delta P/delta t, fractional shortening rate, and the duration of the preejection period, were only modestly enhanced by enoximone. At 2 mg/kg, systemic vascular resistance fell below baseline values without affecting systemic blood pressure; these parameters were not altered by the 1 mg/kg dose. Both pulmonary artery pressure and pulmonary vascular resistance dropped below baseline and below placebo control for the 2 mg/kg dose. Enoximone at 2 mg/kg lowered right and left heart filling pressures below baseline. Examination of regional hemodynamic responses to both doses demonstrated a reduction in limb vascular resistance and an increase in limb blood flow proportional to the concomitant increase in cardiac output. Renal and hepatic-splanchnic blood flow and vascular resistances were not altered by enoximone. First-dose oral enoximone (1 and 2 mg/kg) alters hemodynamics in heart failure by predominant vasodilatation, particularly of limb-musculoskeletal and pulmonary vascular beds, some positive chronotropism, and modest positive inotropism.
- Subjects :
- Adult
Aged
Clinical Trials as Topic
Double-Blind Method
Enoximone
Female
Humans
Imidazoles administration & dosage
Male
Middle Aged
Phosphodiesterase Inhibitors administration & dosage
Heart Failure drug therapy
Hemodynamics drug effects
Imidazoles therapeutic use
Phosphodiesterase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-8703
- Volume :
- 115
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 2966546
- Full Text :
- https://doi.org/10.1016/0002-8703(88)90076-2