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Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.
- Source :
-
Nature genetics [Nat Genet] 2018 May; Vol. 50 (5), pp. 652-656. Date of Electronic Publication: 2018 Apr 16. - Publication Year :
- 2018
-
Abstract
- Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but 13 are novel. Collectively, single-nucleotide polymorphisms associated with hair color within these loci explain 34.6% of red hair, 24.8% of blond hair, and 26.1% of black hair heritability in the study populations. These results confirm the polygenic nature of complex phenotypes and improve our understanding of melanin pigment metabolism in humans.
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 29662168
- Full Text :
- https://doi.org/10.1038/s41588-018-0100-5