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A lectin fraction from green seaweed Caulerpa cupressoides inhibits inflammatory nociception in the temporomandibular joint of rats dependent from peripheral mechanisms.
- Source :
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International journal of biological macromolecules [Int J Biol Macromol] 2018 Aug; Vol. 115, pp. 331-340. Date of Electronic Publication: 2018 Apr 13. - Publication Year :
- 2018
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Abstract
- Temporomandibular disorders are the second most common cause of orofacial pain mediated by inflammatory compounds, which in many cases leads to chronic orofacial pain. This study assessed the antinociceptive and anti-inflammatory effects of a lectin from the green seaweed Caulerpa cupressoides (CcL) on hypernociception inflammatory in TMJ of rats and investigated the involvement of different mechanisms. Rats received i.v. CcL 30 min prior to injection of flogistic agentes or 0.9% saline into the left TMJ. Pretreatment with CcL (0. 1; 1 or 10 mg/kg) promoted a reduction (p < 0.05) of inflammatory hypernociception induced by 1.5% Formalin along with inhibition of inflammatory plasma extravasation, cytokines levels, ciclooxigenase-2, and intercellular adhesion molecule (ICAM-1). CcL was able to inhibit the nociceptive response induced by 1.5% Capsaicin, suggesting that CcL has an antinociceptive effect, acting directly on the primary nociceptive neurons. CcL also inhibited the nociceptive response induced by Carrageenan (100 μg/TMJ) or Serotonin (5-HT) (225 μg/TMJ). In conclusion, the results demonstrate that administration of CcL has a potential antinociceptive and anti-inflammatory effect, with a mechanism that is partially dependent on TNF-α, IL-1β, COX-2 and ICAM-1 inhibition and independently from the cannabinoide and opioid system and NO/cGMP/PKG/K <superscript>+</superscript> <subscript>ATP</subscript> channel pathway.<br /> (Copyright © 2018. Published by Elsevier B.V.)
- Subjects :
- Animals
Cell Adhesion Molecules metabolism
Cyclooxygenase 2 metabolism
Inflammation physiopathology
Interleukin-1beta biosynthesis
Male
Motor Activity drug effects
Nociception drug effects
Rats
Rats, Wistar
Temporomandibular Joint metabolism
Tumor Necrosis Factor-alpha biosynthesis
Analgesics pharmacology
Caulerpa chemistry
Plant Lectins pharmacology
Temporomandibular Joint drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 115
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 29660457
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2018.04.065