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Experience with OK-432 in lymphatic vascular malformations in a hospital from northern Mexico.
- Source :
-
Boletin medico del Hospital Infantil de Mexico [Bol Med Hosp Infant Mex] 2018; Vol. 75 (2), pp. 89-93. - Publication Year :
- 2018
-
Abstract
- Background: Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6000 to -16000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK-432 are being studied. The majority of the studies are small in number of patients and are from Japan; the largest studies in Mexico are focused on specific lesions (macrocystic) or a determined anatomical region. To date, there are no studies of the population of the north of Mexico.<br />Method: The experience with OK-432 was described through a retrospective, descriptive study in patients with LVM, from 2011 to 2016, in a reference hospital of northern Mexico.<br />Results: A total of 26 patients with LVM were treated with OK-432. The majority of the lesions were macrocystic (69 %), microcystic (19 %) and mixed (12 %). From the total number of patients, 11 fully healed, and 72 % of the study population had >50 % reduction in lesion size, with only 2 applications. There were no recurrences. Complications were reported in 2 patients who had skin hyperpigmentation.<br />Conclusions: OK-432 probed to be an effective treatment for LVM in a reference hospital in the north of Mexico.<br /> (Copyright: © 2018 Permanyer.)
- Subjects :
- Antineoplastic Agents adverse effects
Female
Humans
Hyperpigmentation chemically induced
Lymphangioma pathology
Lymphatic Abnormalities pathology
Male
Mexico
Picibanil adverse effects
Retrospective Studies
Treatment Outcome
Antineoplastic Agents therapeutic use
Lymphangioma drug therapy
Lymphatic Abnormalities drug therapy
Picibanil therapeutic use
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1665-1146
- Volume :
- 75
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Boletin medico del Hospital Infantil de Mexico
- Publication Type :
- Academic Journal
- Accession number :
- 29658945
- Full Text :
- https://doi.org/10.24875/BMHIM.M18000013