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Experience with OK-432 in lymphatic vascular malformations in a hospital from northern Mexico.

Authors :
Reyes JAC
Escurra EAM
Rangel JC
Ita JR
Lindemann JL
García LFR
López BJC
Source :
Boletin medico del Hospital Infantil de Mexico [Bol Med Hosp Infant Mex] 2018; Vol. 75 (2), pp. 89-93.
Publication Year :
2018

Abstract

Background: Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6000 to -16000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK-432 are being studied. The majority of the studies are small in number of patients and are from Japan; the largest studies in Mexico are focused on specific lesions (macrocystic) or a determined anatomical region. To date, there are no studies of the population of the north of Mexico.<br />Method: The experience with OK-432 was described through a retrospective, descriptive study in patients with LVM, from 2011 to 2016, in a reference hospital of northern Mexico.<br />Results: A total of 26 patients with LVM were treated with OK-432. The majority of the lesions were macrocystic (69 %), microcystic (19 %) and mixed (12 %). From the total number of patients, 11 fully healed, and 72 % of the study population had >50 % reduction in lesion size, with only 2 applications. There were no recurrences. Complications were reported in 2 patients who had skin hyperpigmentation.<br />Conclusions: OK-432 probed to be an effective treatment for LVM in a reference hospital in the north of Mexico.<br /> (Copyright: © 2018 Permanyer.)

Details

Language :
Spanish; Castilian
ISSN :
1665-1146
Volume :
75
Issue :
2
Database :
MEDLINE
Journal :
Boletin medico del Hospital Infantil de Mexico
Publication Type :
Academic Journal
Accession number :
29658945
Full Text :
https://doi.org/10.24875/BMHIM.M18000013