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Graphene foam as a biocompatible scaffold for culturing human neurons.

Authors :
D'Abaco GM
Mattei C
Nasr B
Hudson EJ
Alshawaf AJ
Chana G
Everall IP
Nayagam B
Dottori M
Skafidas E
Source :
Royal Society open science [R Soc Open Sci] 2018 Mar 07; Vol. 5 (3), pp. 171364. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018).
Publication Year :
2018

Abstract

In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stem cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.<br />Competing Interests: We declare we have no competing interests.

Details

Language :
English
ISSN :
2054-5703
Volume :
5
Issue :
3
Database :
MEDLINE
Journal :
Royal Society open science
Publication Type :
Academic Journal
Accession number :
29657752
Full Text :
https://doi.org/10.1098/rsos.171364