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Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes.

Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes.

Authors :
Valvassori SS
Bavaresco DV
Feier G
Cechinel-Recco K
Steckert AV
Varela RB
Borges C
Carvalho-Silva M
Gomes LM
Streck EL
Quevedo J
Source :
Psychiatry research [Psychiatry Res] 2018 Jun; Vol. 264, pp. 192-201. Date of Electronic Publication: 2018 Apr 04.
Publication Year :
2018

Abstract

The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients. 51 bipolar patients were recruited into this study: 34 in the euthymic phase, and 17 in the depressive phase. Our results indicated that the depressive phase could increase the levels of mitochondrial superoxide, carbonyl and TBARS, and superoxide dismutase, and could decrease the levels of mitochondrial complex II activity in the lymphocytes of bipolar patients. It was also observed that there was a negative correlation between the Hamilton Depression Rating Scale (HDRS) and complex II activity in the lymphocytes of depressive bipolar patients. In addition, there was a positive correlation between HDRS and superoxide, superoxide dismutase, TBARS and carbonyl. Additionally, there was a negative correlation between complex II activity and oxidative stress parameters. In conclusion, our results suggest that mitochondrial oxidative stress and mitochondrial complex II dysfunction play important roles in the depressive phase of BD.<br /> (Copyright © 2018. Published by Elsevier B.V.)

Details

Language :
English
ISSN :
1872-7123
Volume :
264
Database :
MEDLINE
Journal :
Psychiatry research
Publication Type :
Academic Journal
Accession number :
29653348
Full Text :
https://doi.org/10.1016/j.psychres.2018.03.089