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Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-κB/miR-33a pathway in THP-1 macropahge-derived foam cells.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Jun 02; Vol. 500 (2), pp. 318-324. Date of Electronic Publication: 2018 Apr 17. - Publication Year :
- 2018
-
Abstract
- Atherosclerosis is a dyslipidemia disease characterized by foam cell formation driven by the accumulation of lipids. Visceral adipose tissue-derived serine protease inhibitor (vaspin) is known to suppress the development of atherosclerosis via its anti-inflammatory properties, but it is not yet known whether vaspin affects cholesterol efflux in THP-1 macrophage-derived foam cells. Here, we investigated the effects of vaspin on ABCA1 expression and cholesterol efflux, and further explored the underlying mechanism. We found that vaspin decreased miR-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux. We also found that inhibition of NF-κB reduced miR-33a expression and vaspin suppressed LPS-mediated NF-κB phosphorylation. Our findings suggest that vaspin is not only a regular of inflammasion but also a promoter of cholesterol efflux.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- ATP Binding Cassette Transporter 1 genetics
Base Sequence
Cell Line
Down-Regulation
Foam Cells drug effects
Humans
Lipid Metabolism
MicroRNAs genetics
Signal Transduction
ATP Binding Cassette Transporter 1 metabolism
Cholesterol metabolism
Foam Cells metabolism
Intra-Abdominal Fat metabolism
Macrophages cytology
MicroRNAs metabolism
NF-kappa B metabolism
Serpins metabolism
Up-Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 500
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 29653102
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.04.066