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Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis.
- Source :
-
Congenital anomalies [Congenit Anom (Kyoto)] 2019 Mar; Vol. 59 (2), pp. 39-42. Date of Electronic Publication: 2018 May 02. - Publication Year :
- 2019
-
Abstract
- To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant Sprague Dawley (SD) rats in a single dose on day 11 of pregnancy at 25 or 35 mg/kg. Fetuses on day 20 of pregnancy were externally, viscerally, and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35 mg/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs. Our findings indicated that specific types of external and skeletal anomalies were induced following flucytosine administration on day 11 of pregnancy.<br /> (© 2018 Japanese Teratology Society.)
- Subjects :
- Abnormalities, Drug-Induced etiology
Administration, Oral
Animals
Drug Administration Schedule
Eating drug effects
Ectromelia chemically induced
Female
Fetus
Hindlimb abnormalities
Hindlimb drug effects
Lumbosacral Region abnormalities
Male
Maternal Exposure adverse effects
Organogenesis drug effects
Polydactyly chemically induced
Pregnancy
Rats
Rats, Sprague-Dawley
Ribs abnormalities
Ribs drug effects
Weight Gain drug effects
Abnormalities, Drug-Induced pathology
Ectromelia pathology
Fetal Development drug effects
Flucytosine toxicity
Polydactyly pathology
Teratogens toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1741-4520
- Volume :
- 59
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Congenital anomalies
- Publication Type :
- Academic Journal
- Accession number :
- 29653020
- Full Text :
- https://doi.org/10.1111/cga.12282