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Decreases in neprilysin and vasoconstrictors and increases in vasodilators following bariatric surgery.

Authors :
Ghanim H
Monte S
Caruana J
Green K
Abuaysheh S
Dandona P
Source :
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2018 Aug; Vol. 20 (8), pp. 2029-2033. Date of Electronic Publication: 2018 May 02.
Publication Year :
2018

Abstract

The aim of this study was to determine if weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of the renin angiotensin system (RAS), catecholamines and endothelin-1, and also with an increase in the concentrations of vasodilators. Fasting blood samples were obtained from 15 patients with morbid obesity and diabetes prior to and 6 months after RYGB surgery. Circulating levels of neprilysin, vasoconstrictors, vasodilators, and the mRNA expression of related genes in circulating mononuclear cells (MNC) were measured. Six months after RYGB surgery the concentrations of neprilysin, angiotensinogen, angiotensin II, renin and endothelin-1 fell significantly by 27 ±16%, 22 ±10%, 22 ±8%, 35 ±13% and 17 ±6% (P < .05 for all), respectively, while ANP concentrations increased significantly by 24 ±13%. There was no significant change in aldosterone, BNP, cAMP or cGMP concentrations, or angiotensin converting enzyme (ACE) expression. These changes may contribute to the reduction of congestive cardiac failure and blood pressure risks after RYGB surgery.<br /> (© 2018 John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1463-1326
Volume :
20
Issue :
8
Database :
MEDLINE
Journal :
Diabetes, obesity & metabolism
Publication Type :
Academic Journal
Accession number :
29652095
Full Text :
https://doi.org/10.1111/dom.13320