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Decreases in neprilysin and vasoconstrictors and increases in vasodilators following bariatric surgery.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2018 Aug; Vol. 20 (8), pp. 2029-2033. Date of Electronic Publication: 2018 May 02. - Publication Year :
- 2018
-
Abstract
- The aim of this study was to determine if weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of the renin angiotensin system (RAS), catecholamines and endothelin-1, and also with an increase in the concentrations of vasodilators. Fasting blood samples were obtained from 15 patients with morbid obesity and diabetes prior to and 6 months after RYGB surgery. Circulating levels of neprilysin, vasoconstrictors, vasodilators, and the mRNA expression of related genes in circulating mononuclear cells (MNC) were measured. Six months after RYGB surgery the concentrations of neprilysin, angiotensinogen, angiotensin II, renin and endothelin-1 fell significantly by 27 ±16%, 22 ±10%, 22 ±8%, 35 ±13% and 17 ±6% (P < .05 for all), respectively, while ANP concentrations increased significantly by 24 ±13%. There was no significant change in aldosterone, BNP, cAMP or cGMP concentrations, or angiotensin converting enzyme (ACE) expression. These changes may contribute to the reduction of congestive cardiac failure and blood pressure risks after RYGB surgery.<br /> (© 2018 John Wiley & Sons Ltd.)
- Subjects :
- Body Mass Index
Diabetes Mellitus, Type 2 complications
Diabetic Angiopathies epidemiology
Diabetic Angiopathies prevention & control
Diabetic Cardiomyopathies epidemiology
Diabetic Cardiomyopathies prevention & control
Female
Glycated Hemoglobin analysis
Heart Failure complications
Heart Failure epidemiology
Heart Failure etiology
Humans
Hypertension complications
Hypertension epidemiology
Hypertension etiology
Insulin Resistance
Male
Middle Aged
Obesity, Morbid complications
Obesity, Morbid metabolism
Obesity, Morbid physiopathology
Postoperative Period
Prospective Studies
Risk
Weight Loss
Bariatric Surgery adverse effects
Endothelin-1 blood
Heart Failure prevention & control
Hypertension prevention & control
Neprilysin blood
Obesity, Morbid surgery
Renin-Angiotensin System
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 29652095
- Full Text :
- https://doi.org/10.1111/dom.13320