Suppression of contractile force in muscle fibers by antibody to myosin subfragment 2.

Authors :: Lovell S
Karr T
Harrington WF
Source :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1988 Mar; Vol. 85 (6), pp. 1849-53.
Publication Year :: 1988
Abstract: Polyclonal antibody directed against the subfragment-2 region of myosin was purified by affinity chromatography. Skinned muscle fibers that had been preincubated with antibody were able to sustain only 7% of the active isometric force generated by control fibers. The effect of antibody on force production could not be accounted for by inhibition of ATP turnover.

Subjects :: Adenosine Triphosphatases metabolism
Animals
Chickens
Glycine
Immunoglobulin Fab Fragments metabolism
Myosin Subfragments
Rats
Antibodies
Muscle Contraction
Myosins immunology
Peptide Fragments immunology

Language :: English
ISSN :: 0027-8424
Volume :: 85
Issue :: 6
Database :: MEDLINE
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 2964637
Full Text :: https://doi.org/10.1073/pnas.85.6.1849

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