Back to Search
Start Over
Proof of concept: liver splitting during normothermic machine perfusion.
- Source :
-
Journal of surgical case reports [J Surg Case Rep] 2018 Mar 28; Vol. 2018 (3), pp. rjx218. Date of Electronic Publication: 2018 Mar 28 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Introduction: Despite utilizing extended criteria donors, there remains a shortage of livers for transplantation. No data exists on splitting donor livers with concurrent NMP-L.<br />Methods: A liver recovered from a donor after circulatory death was subjected to NMP-L using a red cell based fluid. During NMP-L, a 'classical' left lateral + right trisegmentectomy split was performed using an integrated bipolar/ultrasonic device. After splitting, blood flow was confirmed using Doppler ultrasound in each lobe.<br />Results: Prior to splitting, flow rates were maintained physiologically. Lactate decreased from 13.9 to 3.0 mmol/L. Lactate before and after splitting were similar in the hepatic arteries, portal veins and IVC. Doppler ultrasound demonstrated arterial and venous waveforms in both lobes after splitting.<br />Conclusions: 'Classical' liver splitting during NMP-L is feasible, maintaining viability of both lobes. Establishing this procedure may attenuate cold ischaemic injury, allow pre-implantation monitoring of both grafts and facilitate logistics of transplanting two grafts.
Details
- Language :
- English
- ISSN :
- 2042-8812
- Volume :
- 2018
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of surgical case reports
- Publication Type :
- Report
- Accession number :
- 29644030
- Full Text :
- https://doi.org/10.1093/jscr/rjx218