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Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center.

Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center.

Authors :
Tfayli H
Charafeddine L
Tamim H
Saade J
Daher RT
Yunis K
Source :
Hormone research in paediatrics [Horm Res Paediatr] 2018; Vol. 89 (4), pp. 224-232. Date of Electronic Publication: 2018 Apr 11.
Publication Year :
2018

Abstract

Background/aims: Preterm newborns with a very low birth weight (VLBW) of < 1,500 g have an atypical form of hypothyroidism with a delayed rise in TSH, necessitating a second newborn screening specimen collection. The aims of this study were to survey the compliance with second newborn screening to detect delayed TSH rise in VLBW preterm infants at a tertiary care center, and to determine the rate of atypical hypothyroidism.<br />Methods: Retrospective review of the records of 104 preterm VLBW infants. Late TSH rise was defined as an increase in TSH concentration after 14 days of age in the presence of a normal initial screen.<br />Results: The compliance rate was 92% for the second screening. High rates of hypothyroidism (16.3%) and of late TSH rise (4.8%) were detected. Patients with hypothyroidism had a significantly lower birth weight (p = 0.01) and longer hospital stay (p = 0.004). Patients with late versus those with early TSH rise had a significantly lower mean birth weight (851 ± 302 vs. 1,191 ± 121 g, p = 0.004).<br />Conclusion: The rates of early and late TSH rise in this VLBW population were higher than those in the literature and could be due to the use of povidone-iodine disinfectants. The yield of a second TSH screening in this study was high indicating the need for vigilance in screening VLBW preterm infants.<br /> (© 2018 S. Karger AG, Basel.)

Details

Language :
English
ISSN :
1663-2826
Volume :
89
Issue :
4
Database :
MEDLINE
Journal :
Hormone research in paediatrics
Publication Type :
Academic Journal
Accession number :
29642061
Full Text :
https://doi.org/10.1159/000487637