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Physiologically Based Pharmacokinetic Modeling in Pregnancy: A Systematic Review of Published Models.
- Source :
-
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2018 Dec; Vol. 104 (6), pp. 1110-1124. Date of Electronic Publication: 2018 May 06. - Publication Year :
- 2018
-
Abstract
- During recent years there has been a surge in developing and applying physiologically based pharmacokinetic (PBPK) models in pregnant women to better understand and predict changes in drug pharmacokinetics throughout pregnancy. As a consequence, the number of publications focusing on pregnancy PBPK models has increased substantially. However, to date these models, especially across various platforms, have not been systematically evaluated. Hence, this review aims to assess published PBPK models in pregnancy used for therapeutic purposes.<br /> (© 2018 American Society for Clinical Pharmacology and Therapeutics.)
- Subjects :
- Animals
Dosage Forms
Drug Administration Routes
Drug Interactions
Drug-Related Side Effects and Adverse Reactions etiology
Enzyme Inhibitors administration & dosage
Enzyme Inhibitors adverse effects
Enzyme Inhibitors blood
Female
Gastrointestinal Absorption
Gestational Age
Humans
Lactation
Maternal Exposure
Maternal-Fetal Exchange
Membrane Transport Modulators administration & dosage
Membrane Transport Modulators adverse effects
Membrane Transport Modulators blood
Models, Biological
Patient Safety
Placental Circulation
Pregnancy
Risk Assessment
Risk Factors
Species Specificity
Drug Development methods
Enzyme Inhibitors pharmacokinetics
Membrane Transport Modulators pharmacokinetics
Pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-6535
- Volume :
- 104
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 29633257
- Full Text :
- https://doi.org/10.1002/cpt.1084