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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
- Source :
-
Nature communications [Nat Commun] 2018 Apr 09; Vol. 9 (1), pp. 1340. Date of Electronic Publication: 2018 Apr 09. - Publication Year :
- 2018
-
Abstract
- Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10 <superscript>-9</superscript> , odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10 <superscript>-8</superscript> , OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
- Subjects :
- Child
Child, Preschool
Core Binding Factor Alpha 2 Subunit genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Glycosyltransferases genetics
HLA Antigens genetics
Humans
Male
Oncogene Proteins, Fusion genetics
Polymorphism, Single Nucleotide
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma immunology
Prognosis
Risk Factors
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 29632299
- Full Text :
- https://doi.org/10.1038/s41467-018-03178-z