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Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: A split-mouth randomized clinical trial.
- Source :
-
Quintessence international (Berlin, Germany : 1985) [Quintessence Int] 2018; Vol. 49 (5), pp. 377-388. - Publication Year :
- 2018
-
Abstract
- Objectives: The purpose of this study was to evaluate the influence of leukocyte- and platelet-rich fibrin (L-PRF) on impacted mandibular third molar (IMTM) extraction wound healing, patient postoperative discomfort, and incidence of alveolar osteitis.<br />Method and Materials: Thirty-four patients (20 female, 14 male) who met the inclusion criteria for this split-mouth randomized clinical trial were enrolled and 30 patients completed the study. Patients were randomized and underwent bilateral IMTM surgical extractions. Following extraction, one socket randomly received L-PRF, and the other socket served as a regular blood clot control. Postoperatively, the soft tissue healing index (HI), pain according to visual analog scale (VAS), facial swelling using a horizontal and vertical guide, and incidence of alveolar osteitis were evaluated 1, 3, 7, and 14 days after surgery.<br />Results: Sites treated with L-PRF resulted in improved HI (P = .001) and lower pain VAS scores (P = .001) in the first postoperative week. Significant reduction of facial swelling was recorded on first (P = .035) and third (P = .023) postoperative days in L-PRF sites versus controls, ceasing to nonsignificant difference at day 7 (P = .224). None of the L-PRF sites and four control sites were affected by alveolar osteitis (P = .001).<br />Conclusion: Within the limitations of this split-mouth study, L-PRF improved soft tissue healing and reduced postoperative pain, swelling, and incidence of alveolar osteitis after IMTM surgical extractions.
- Subjects :
- Dry Socket prevention & control
Edema prevention & control
Female
Humans
Male
Pain Measurement
Pain, Postoperative prevention & control
Prospective Studies
Tooth Extraction methods
Treatment Outcome
Young Adult
Molar, Third surgery
Platelet-Rich Fibrin physiology
Tooth, Impacted surgery
Wound Healing physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1936-7163
- Volume :
- 49
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Quintessence international (Berlin, Germany : 1985)
- Publication Type :
- Academic Journal
- Accession number :
- 29629438
- Full Text :
- https://doi.org/10.3290/j.qi.a40113