Back to Search
Start Over
Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia.
- Source :
-
Journal of neurology [J Neurol] 2018 Jun; Vol. 265 (6), pp. 1381-1392. Date of Electronic Publication: 2018 Apr 07. - Publication Year :
- 2018
-
Abstract
- Introduction: We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).<br />Methods: Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.<br />Results: MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.<br />Discussion: Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.
- Subjects :
- Adult
Cognitive Dysfunction diagnosis
Cognitive Dysfunction genetics
Female
Follow-Up Studies
Frontotemporal Dementia genetics
Genetic Predisposition to Disease
Heterozygote
Humans
Intercellular Signaling Peptides and Proteins genetics
Longitudinal Studies
Male
Middle Aged
Multilevel Analysis
Mutation
Neuropsychological Tests
Prodromal Symptoms
Prognosis
Progranulins
ROC Curve
Regression Analysis
tau Proteins genetics
Frontotemporal Dementia diagnosis
Frontotemporal Dementia psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 265
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 29627938
- Full Text :
- https://doi.org/10.1007/s00415-018-8850-7