Back to Search
Start Over
Psoas and paraspinous muscle index as a predictor of mortality in African American men with type 2 diabetes mellitus.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2018 Jun; Vol. 32 (6), pp. 558-564. Date of Electronic Publication: 2018 Mar 19. - Publication Year :
- 2018
-
Abstract
- Aim: Recent studies revealed a correlation between skeletal muscle mass index and density with longevity; these studies largely evaluated appendicular skeletal muscles in older Caucasians. This retrospective cohort study assessed the association between axial skeletal muscles size and density with survival in African Americans with type 2 diabetes mellitus.<br />Methods: Psoas and paraspinous muscle mass index (cross sectional area/height <superscript>2</superscript> ) and radiographic density (in Hounsfield Units) were measured using computed tomography in African American-Diabetes Heart Study participants, 314 women and 256 men, with median (25th, 75th quartile) age 55.0(48.0, 62.0) and 57.0(50.0, 64.0) years, respectively. Covariates in fully-adjusted model included age, sex, BMI, smoking, hormone replacement therapy (women), cardiovascular disease, hypertension, coronary artery calcified plaque mass, carotid artery calcified plaque mass, and African ancestry proportion.<br />Results: After median of 7.1(5.9, 8.2) years follow-up, 30(9.6%) of women and 49(19.1%) of men were deceased. In fully-adjusted models, psoas muscle mass index and paraspinous muscle mass index were inversely associated with mortality in men (psoas muscle mass index, hazard ratio [HR] = 0.61, P = 0.004; paraspinous muscle mass index, HR = 0.64, P = 0.004), but not in women. Psoas and paraspinous muscle densities did not associate with all-cause mortality. A penalized Cox regression that involved all covariates and predictors associated with mortality showed that only paraspinous muscle mass index remained a significant predictor of mortality (HR = 0.65, P = 0.02).<br />Conclusion: Independent from established risk factors for mortality, higher psoas and paraspinous muscle index associate with reduced all-cause mortality in middle-aged African American men with type 2 diabetes mellitus.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Body Composition physiology
Cross-Sectional Studies
Diabetes Mellitus, Type 2 ethnology
Health Status Indicators
Humans
Male
Middle Aged
Paraspinal Muscles diagnostic imaging
Prognosis
Psoas Muscles diagnostic imaging
Retrospective Studies
Survival Analysis
Tomography, X-Ray Computed
Black or African American statistics & numerical data
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 mortality
Paraspinal Muscles pathology
Psoas Muscles pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 29627372
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2018.03.004