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Severe inflammatory ileitis resulting in ileal perforation in association with combination immune checkpoint blockade for metastatic malignant melanoma.
- Source :
-
BMJ case reports [BMJ Case Rep] 2018 Apr 05; Vol. 2018. Date of Electronic Publication: 2018 Apr 05. - Publication Year :
- 2018
-
Abstract
- Immune checkpoint inhibitors have become standard of care in metastatic malignant melanoma management. Despite superior effectiveness to chemotherapy, significant immune-related adverse events (irAE) may occur, particularly if used in combination. Gastrointestinal irAEs were reported with different patterns of involvement. Here, we report the case of a patient who had ileal perforation as a complication of terminal ileitis, without colitis, induced by combination immune checkpoint blockade.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Subjects :
- Antineoplastic Agents adverse effects
Female
Humans
Ileitis complications
Intestinal Perforation therapy
Middle Aged
Treatment Outcome
Drug Therapy, Combination adverse effects
Ileitis chemically induced
Intestinal Perforation chemically induced
Ipilimumab adverse effects
Melanoma drug therapy
Vulvar Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 2018
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 29622719
- Full Text :
- https://doi.org/10.1136/bcr-2018-224913