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Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2018 Aug; Vol. 53, pp. 13-21. Date of Electronic Publication: 2018 Apr 02. - Publication Year :
- 2018
-
Abstract
- CD4 T cells play a multiplicity of roles in protective immunity to influenza. Included in these functions are help for high affinity antibody production, enhancement of CD8 T cell expansion, function and memory, acceleration of the early innate response to infection and direct cytotoxicity. The influenza-specific CD4 T cell repertoire in humans established through exposures to infection and vaccination has been found to be highly variable in abundance, specificity and functionality. Deficits in particular subsets of CD4 T cells recruited into the response result in diminished antibody responses and protection from infection. Therefore, improved strategies for vaccination should include better methods to identify deficiencies in the circulating CD4 T cell repertoire, and vaccine constructs that increase the representation of CD4 T cells of the correct specificity and functionality.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antibodies, Viral metabolism
Antibody Formation
Antigens, Viral immunology
CD8-Positive T-Lymphocytes immunology
Humans
Immunity, Cellular
T-Cell Antigen Receptor Specificity
Vaccination
CD4-Positive T-Lymphocytes immunology
Influenza Vaccines immunology
Influenza, Human immunology
Orthomyxoviridae immunology
Orthomyxoviridae Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0372
- Volume :
- 53
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29621639
- Full Text :
- https://doi.org/10.1016/j.coi.2018.03.019