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Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2018; Vol. 63 (1), pp. 149-155. - Publication Year :
- 2018
-
Abstract
- We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging. We investigated if leisure-time physical activity among individuals with mild cognitive impairment (MCI) was associated with a decreased risk of developing dementia. 280 persons aged≥70 years (median 81 years, 165 males) with MCI and available data from neurologic evaluation, neuropsychological testing, and questionnaire-based physical activity assessment, were followed for a median of 3 years to the outcomes of incident dementia or censoring variables. We conducted Cox proportional hazards regression analyses with age as a time scale and adjusted for sex, education, medical comorbidity, depression, and APOE ɛ4 status. Moderate intensity midlife physical activity among MCI participants was significantly associated with a decreased risk of incident dementia (HR = 0.64; 95% CI, 0.41-0.98). There was a non-significant trend for a decreased risk of dementia for light and vigorous intensity midlife physical activity, as well as light and moderate intensity late-life physical activity. In conclusion, we observed that physical activity may be associated with a reduced risk of dementia among individuals with MCI. Furthermore, intensity and timing of physical activity may be important factors when investigating this association.
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Apolipoprotein E4 genetics
Cognition Disorders epidemiology
Cognition Disorders physiopathology
Cognition Disorders psychology
Cohort Studies
Community Health Planning
Dementia genetics
Dementia psychology
Female
Humans
Incidence
Male
Neuropsychological Tests
Self Report
Aging
Dementia epidemiology
Dementia physiopathology
Exercise physiology
Leisure Activities psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 63
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 29614667
- Full Text :
- https://doi.org/10.3233/JAD-171141