Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo.

Authors :: Kakabadze E
Makalatia K
Grdzelishvili N
Bakuradze N
Goderdzishvili M
Kusradze I
Phoba MF
Lunguya O
Lood C
Lavigne R
Jacobs J
Deborggraeve S
De Block T
Van Puyvelde S
Lee D
Coffey A
Sedrakyan A
Soentjens P
De Vos D
Pirnay JP
Chanishvili N
Source :: Viruses [Viruses] 2018 Apr 03; Vol. 10 (4). Date of Electronic Publication: 2018 Apr 03.
Publication Year :: 2018
Abstract: Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S . Typhi, and Salmonella in general.<br />Competing Interests: The authors declare no conflict of interest.

Subjects :: Bacteriolysis
Bacteriophages classification
Bacteriophages ultrastructure
Democratic Republic of the Congo
Genome, Viral
Humans
Phage Therapy
Phylogeny
Salmonella typhi isolation & purification
Typhoid Fever therapy
Bacteriophages physiology
Salmonella typhi genetics
Salmonella typhi virology
Typhoid Fever microbiology
beta-Lactamases genetics

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